DNA topoisomerase I drugs and radiotherapy for lung cancer.

  title={DNA topoisomerase I drugs and radiotherapy for lung cancer.},
  author={Allan Y. Chen and Patricia M T Chen and Yi-Jen Chen},
  journal={Journal of thoracic disease},
  volume={4 4},
Lung cancer represents the most common cause of cancer-related mortality in the United States and around the world. DNA topoisomerase I (TOP1) drugs such as irinotecan and topotecan represent a unique class of chemotherapeutic agents that exhibit not only potent cytotoxic effect, but also tumor-selective radiation-sensitizing effect. The mechanism of cytotoxicity and radiation sensitization by TOP1 drugs has been intensely investigated. Modern radiotherapy, aided by improved imaging and… CONTINUE READING
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