DNA-templated synthesis of trimethine cyanine dyes: a versatile fluorogenic reaction for sensing G-quadruplex formation.

@article{Meguellati2010DNAtemplatedSO,
  title={DNA-templated synthesis of trimethine cyanine dyes: a versatile fluorogenic reaction for sensing G-quadruplex formation.},
  author={Kamel Meguellati and Girish K Koripelly and Sylvain Ladame},
  journal={Angewandte Chemie},
  year={2010},
  volume={49 15},
  pages={2738-42}
}
It has been known for several decades that G-rich nucleic acid sequences have a propensity to fold into highly stable four-stranded structures in vitro in the presence of physiological cations, notably K and Na. Such structures, termed quadruplexes, have had their biological significance demonstrated for a number of processes. For example, it has been shown that the single-stranded 3’-end of telomeric DNA could adopt a quadruplex conformation under near physiological conditions, which has… CONTINUE READING
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