DNA-templated organic synthesis and selection of a library of macrocycles.

  title={DNA-templated organic synthesis and selection of a library of macrocycles.},
  author={Zev J Gartner and Brian N Tse and Rozalina Grubina and Jeffrey B. Doyon and Thomas M. Snyder and David R Liu},
  volume={305 5690},
The translation of nucleic acid libraries into corresponding synthetic compounds would enable selection and amplification principles to be applied to man-made molecules. We used multistep DNA-templated organic synthesis to translate libraries of DNA sequences, each containing three "codons," into libraries of sequence-programmed synthetic small-molecule macrocycles. The resulting DNA-macrocycle conjugates were subjected to in vitro selections for protein affinity. The identity of a single… CONTINUE READING


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