DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors.

@article{Russell1995DNASA,
  title={DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors.},
  author={David W. Russell and Ian E. Alexander and A Dusty Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 12},
  pages={5719-23}
}
Viral vectors based on adeno-associated virus (AAV) preferentially transduce cells in S phase of the cell cycle. We recently found that DNA-damaging agents increased the transduction of nondividing cells. However, the optimal concentrations were toxic to cells. Here we show that the transduction of normal human fibroblasts by AAV vectors is increased by prior exposure to DNA synthesis inhibitors, such as aphidicolin or hydroxyurea, and topoisomerase inhibitors, such as etoposide or camptothecin… CONTINUE READING

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