DNA synthesis and biological security

  title={DNA synthesis and biological security},
  author={Hans Bügl and John P. Danner and Robert J. Molinari and John T Mulligan and Hanee Park and B. Reichert and David A. Roth and Ralf Wagner and Bruce Budowle and Robert M. Scripp and Jenifer A.L. Smith and Scott Steele and George M. Church and Drew Endy},
  journal={Nature Biotechnology},
A group of academics, industry executives and security experts propose an oversight framework to address concerns over the security of research involving commercial DNA synthesis. 

Proliferation-resistant biotechnology: an approach to improve biological security

Is there a way to design DNA synthesis technology with safeguards that prevent its cooption for nefarious purposes?

Securing the Future of Biotechnology: A Study of Emerging Bio-Cyber Security Threats to DNA-Information Systems

  • P. Ney
  • Computer Science, Engineering
  • 2019
The future of biotechnology is under threat from cyber attacks, according to a study of emerging Bio-Cyber Security Threats to DNA-Information Systems.

Mitigating security issues in the evolving DNA synthesis industry

DNA synthesis technologies are advancing at exponential rates, with production of ever longer, more complex, and less expensive sequences of double stranded DNA. This has fostered development of

DNA synthesis security.

The historical background and current challenges associated with dual-use biotechnologies are described and strategies to address these challenges are proposed.

Reconstruction of the Genomes

Advances in DNA sequencing and synthesis technologies are making it possible to read and write entire genomes, and new approaches are being developed to combine these technologies to create whole genomes.

Ensuring the security of synthetic biology—towards a 5P governance strategy

  • A. Kelle
  • Computer Science
    Systems and Synthetic Biology
  • 2009
Based on the analysis of biosecurity issues surrounding synthetic biology during the SYNBIOSAFE project, a rationale for taking security, in addition to safety aspects of this new field, seriously is provided.

Cyberbiosecurity: Remote DNA Injection Threat in Synthetic Biology

An improved screening protocol is proposed that implements the top homology principle and considers the possibility of in vivo gene editing and the need to harden the synthetic DNA supply chain with protections against cyberbiosecurity threats.

Security Issues Related to Synthetic Biology

A new 5P-strategy for synthetic biology biosecurity governance which revolves around a set of measures being identified that could be brought to bear at the identified five policy intervention points is outlined.

Engineering Scalable Biological Systems Accessed Terms of Use

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Microbial Forensics☆




Synthetic biologists face up to security issues

Do technological advances need new rules?

Summary statement of the Asilomar conference on recombinant DNA molecules.

This meeting was organized to review scientific progress in research on recombinant DNA molecules and to discuss appropriate ways to deal with the potential biohazards of this work. Impressive

Deoxyribonucleic acid synthesis in cell-free extracts. 3. Catalytic properties of deoxyribonucleic acid polymerase II.

It is shown that DNA polymerase II possesses exonuclease activity which is specific for single stranded DNA, and the direction of attack is exclusively 3' to 5'.

Construction of biologically functional bacterial plasmids in vitro.

Newly constructed plasmids that are inserted into Escherichia coli by transformation are shown to be biologically functional replicons that possess genetic properties and nucleotide base sequences from both of the parent DNA molecules.

The pace and proliferation of biological technologies.

  • Robert Carlson
  • Education
    Biosecurity and bioterrorism : biodefense strategy, practice, and science
  • 2003
The general improvement of technologies used in measuring and manipulating molecules will soon enable a broad and distributed enhancement in the ability to alter biological systems, contributing to a proliferation that will soon put highly capable tools in the hands of both professionals and amateurs worldwide.

Engineering life: building a fab for biology.

Sars Coronavirus Vaccine Development

Given the significant health and economic impact of the SARS-CoV outbreak, an effective vaccine strategy for SARS that includes protection against epidemic and zoontoic strains of virus in at risk elderly populations who are most vulnerable to severe disease is essential.

Biosecur. Bioterror

  • Biosecur. Bioterror
  • 2003

Proc. Natl. Acad. Sci. USA. 70

  • Proc. Natl. Acad. Sci. USA. 70
  • 1973

Extreme Genetic Engineering: An Introduction to Synthetic Biology, published online January 2007 <http://www.etcgroup.org/upload/ publication/602/01/synbioreportweb.pdf>

  • 2007