DNA supercoiling allows enhancer action over a large distance.

@article{Liu2001DNASA,
  title={DNA supercoiling allows enhancer action over a large distance.},
  author={Yewei Liu and Vladamir Bondarenko and Alex Ninfa and Vasily M. Studitsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 26},
  pages={
          14883-8
        }
}
Enhancers are regulatory DNA elements that can activate their genomic targets over a large distance. The mechanism of enhancer action over large distance is unknown. Activation of the glnAp2 promoter by NtrC-dependent enhancer in Escherichia coli was analyzed by using a purified system supporting multiple-round transcription in vitro. The data suggest that DNA supercoiling is an essential requirement for enhancer action over a large distance (2,500 bp) but not over a short distance (110 bp… CONTINUE READING

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