DNA structural alterations induced by bis-netropsins modulate human DNA topoisomerase I cleavage activity and poisoning by camptothecin.

@article{Sukhanova2002DNASA,
  title={DNA structural alterations induced by bis-netropsins modulate human DNA topoisomerase I cleavage activity and poisoning by camptothecin.},
  author={Alyona Sukhanova and Sergei L. Grokhovsky and Michael Ermishov and Konstantin E Mochalov and A. L. Zhuze and Vladimir Oleinikov and Igor Nabiev},
  journal={Biochemical pharmacology},
  year={2002},
  volume={64 1},
  pages={79-90}
}
Bis-netropsins (bis-Nts) are efficient catalytic inhibitors of human DNA topoisomerase I (top I). These DNA minor groove binders are considered to serve as suppressors of top I-linked DNA breaks, which is generally believed to be related to their affinity to DNA. In this study, it was found that bis-Nts exhibit sequence-specificity of suppression of the strong top I-specific DNA cleavage sites and that this sequence-specificity is determined by differential ligand-induced structural alterations… CONTINUE READING