DNA strand specificity for UV-induced mutations in mammalian cells.

  title={DNA strand specificity for UV-induced mutations in mammalian cells.},
  author={Harry Vrieling and Marianne van Rooijen and Nicole A. Groen and Massgorzata Z Zdzienicka and Johannes Simons and Paul H. M. Lohman and Albert A. van Zeeland},
  journal={Molecular and cellular biology},
  volume={9 3},
The influence of DNA repair on the molecular nature of mutations induced by UV light (254 nm) was investigated in UV-induced hprt mutants from UV-sensitive Chinese hamster cells (V-H1) and the parental line (V79). The nature of point mutations in hprt exon sequences was determined for 19 hprt mutants of V79 and for 17 hprt mutants of V-H1 cells by sequence analysis of in vitro-amplified hprt cDNA. The mutation spectrum in V79 cells consisted of single- and tandem double-base pair changes, while… CONTINUE READING

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