DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.

  title={DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.},
  author={Nabil Hajji and Nuria Pastor and Santiago Mateos and Inmaculada Dom{\'i}nguez and F. Cortes},
  journal={Mutation research},
  volume={530 1-2},
The bis-dioxopiperazine ICRF-193 has long time been considered as a pure topoisomerase II catalytic inhibitor able to exert its inhibitory effect on the enzyme without stabilization of the so-called cleavable complex formed by DNA covalently bound to topoisomerase II. In recent years, however, this concept has been challenged, as a number of reports have shown that ICRF-193 really "poisons" the enzyme, most likely through a different mechanism from that shown by the classical topoisomerase II… CONTINUE READING


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