DNA strand breaks induced by hydrogen peroxide in isolated rat hepatocytes.

@article{Olson1988DNASB,
  title={DNA strand breaks induced by hydrogen peroxide in isolated rat hepatocytes.},
  author={M J Olson},
  journal={Journal of toxicology and environmental health},
  year={1988},
  volume={23 3},
  pages={407-23}
}
  • M J Olson
  • Published 1988 in Journal of toxicology and environmental health
It has been proposed that increased rates of hepatic hydrogen peroxide (H2O2) production may initiate or promote the liver tumors that appear following chronic exposure of rodents to chemicals that cause peroxisome proliferation. However, the effect of H2O2 on the structural integrity of DNA in parenchymal hepatocytes, the target cells of peroxisome proliferator-induced carcinogenesis, is largely uncharacterized. Furthermore, oxidant-induced cellular damage has been invoked as causal of a… CONTINUE READING

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