DNA strand breaking by the carbon-centered radical generated from 4-(hydroxymethyl) benzenediazonium salt, a carcinogen in mushroom Agaricus bisporus.

@article{Hiramoto1995DNASB,
  title={DNA strand breaking by the carbon-centered radical generated from 4-(hydroxymethyl) benzenediazonium salt, a carcinogen in mushroom Agaricus bisporus.},
  author={Kazuyuki Hiramoto and Masaru Kaku and Tomoki Kato and Kiyomi Kikugawa},
  journal={Chemico-biological interactions},
  year={1995},
  volume={94 1},
  pages={
          21-36
        }
}
4-(Hydroxymethyl)benzenediazonium salt (HMBD), a carcinogen in mushroom Agaricus bisporus, was found to generate a carbon-centered radical, 4-(hydroxymethyl)phenyl radical, during incubation at pH 7.4 and 37 degrees C, when estimated by Electron Spin Resonance (ESR) spin-trapping technique using 5,5-dimethyl-1-pyrroline N-oxide (DMPO), N-tert-butylphenyl-alpha-nitrone (PBN) and 3,5-dibromo-4-nitrosobenzene sulfonate (DBNBS). Formation of a substantial amount of benzyl alcohol during incubation… CONTINUE READING
BETA

Similar Papers

Loading similar papers…