DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite.

  • Czaba Szabó
  • Published 1996 in Free radical biology & medicine

Abstract

Peroxynitrite is a reactive oxidant produced from nitric oxide (NO) and superoxide. Although its reactivity and decomposition are very much dependent on the constituents of the cellular environment, peroxynitrite is considered a potent oxidant that reacts with proteins, lipids, and DNA. Inasmuch as peroxynitrite is formed in many pathophysiological… (More)

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Cite this paper

@article{Szab1996DNASB, title={DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite.}, author={Czaba Szab{\'o}}, journal={Free radical biology & medicine}, year={1996}, volume={21 6}, pages={855-69} }