DNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instability

@inproceedings{SalinasRios2011DNASC,
  title={DNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instability},
  author={Viviana Salinas-Rios and Boris P. Belotserkovskii and Philip C. Hanawalt},
  booktitle={Nucleic acids research},
  year={2011}
}
The abnormal number of repeats found in triplet repeat diseases arises from 'repeat instability', in which the repetitive section of DNA is subject to a change in copy number. Recent studies implicate transcription in a mechanism for repeat instability proposed to involve RNA polymerase II (RNAPII) arrest caused by a CTG slip-out, triggering transcription-coupled repair (TCR), futile cycles of which may lead to repeat expansion or contraction. In the present study, we use defined DNA constructs… CONTINUE READING