DNA sequencing with stacked nanopores and exonuclease: A simulation-based analysis.

Abstract

Experiments have shown that DNA can be sequenced using an electrolytic cell with a nanopore and an exonuclease enzyme in the cis chamber that cleaves the leading mononucleotide in a strand of DNA. The base therein can be identified with an accuracy of 80-90% by the level of the current blockade caused in the pore; a biological adapter inside slows down the… (More)
DOI: 10.1002/elps.201600049

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