DNA sequencing: bench to bedside and beyond†

  title={DNA sequencing: bench to bedside and beyond†},
  author={Clyde A. Hutchison},
  booktitle={Nucleic acids research},
Fifteen years elapsed between the discovery of the double helix (1953) and the first DNA sequencing (1968). Modern DNA sequencing began in 1977, with development of the chemical method of Maxam and Gilbert and the dideoxy method of Sanger, Nicklen and Coulson, and with the first complete DNA sequence (phage X174), which demonstrated that sequence could give profound insights into genetic organization. Incremental improvements allowed sequencing of molecules >200 kb (human cytomegalovirus… CONTINUE READING
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