DNA sequences required for regulated expression of β-globin genes in murine erythroleukemia cells

@article{Wright1984DNASR,
  title={DNA sequences required for regulated expression of $\beta$-globin genes in murine erythroleukemia cells},
  author={Stephanie Wright and Amon Rosenthal and Richard A. Flavell and Frank G. Grosveld},
  journal={Cell},
  year={1984},
  volume={38},
  pages={265-273}
}

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References

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TLDR
It is shown here that expression of the β, but not the γ or ε genes, is regulated during MEL differentiation.
DNA sequences necessary for transcription of the rabbit β-globin gene in vivo
TLDR
Comparison of the level of β-globin transcripts in a variety of deletion mutants shows that for efficient transcription, both the ATA or Goldberg–Hogness box, and a region between 100 and 58 base pairs in front of the site at which transcription is initiated, are required.
The 5'-flanking region of a human IFN-alpha gene mediates viral induction of transcription.
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It is concluded that induction acts by activating transcription rather than by reducing turnover, and that the regulatory elements are contained in the 5'-flanking region of the interferon gene.
Sequence requirements for the transcription of the rabbit beta-globin gene in vivo: the -80 region.
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Analysis of DNA sequences in the -80 region of the rabbit beta-globin gene shows that the conserved GGCCAATCT sequence is required for efficient transcription in vivo and further identifies another sequence in the region from about -81 to -96 which is also required for transcription in vitro.
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Thymidine kinase negative (TK‐) Friend cells were transformed with recombinant molecules carrying human globin genes and the thymidine kinase gene of herpes simplex virus type 1 DNA. Transformation
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