DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption.

@article{Prior2006DNASV,
  title={DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption.},
  author={Steven J Prior and James M Hagberg and Chad Michael Paton and Larry W. Douglass and Michael D Brown and John Mclenithan and Stephen M Roth},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 5},
  pages={H1848-55}
}
In its role as an endothelial cell proliferation and migration factor, vascular endothelial growth factor (VEGF) can affect peripheral circulation and therefore impact maximal oxygen consumption (Vo2 max). Because of the role of VEGF, and because variation in the VEGF gene has the ability to alter VEGF gene expression and VEGF protein level, we hypothesized that VEGF gene polymorphisms are related to VEGF gene expression in human myoblasts and Vo2 max before and after aerobic exercise training… CONTINUE READING