DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity

@article{Fan2007DNASV,
  title={DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity},
  author={Bao Jian Fan and Louis R. Pasquale and Cynthia L. Grosskreutz and Douglas J. Rhee and Teresa C. Chen and Margaret M Deangelis and Ivana K. Kim and Elizabeth A del Bono and Joan W Miller and Tai-Hang Li and Jonathan L. Haines and Janey L. Wiggs},
  journal={BMC Medical Genetics},
  year={2007},
  volume={9},
  pages={5 - 5}
}
Pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. Using a U.S. clinic-based case control sample with broad ethnic diversity, we show that three common SNPs in LOXL1 previously associated with pseudoexfoliation in Nordic populations are significantly associated with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Three LOXL1 SNPs were genotyped in a patient sample (206 pseudoexfoliation, 331 primary open angle glaucoma, and 88… CONTINUE READING
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