DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae

@article{Heidelberg2000DNASO,
  title={DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae},
  author={John F. Heidelberg and Jonathan A. Eisen and William C. Nelson and Rebecca A. Clayton and Michelle L. Gwinn and Robert J. Dodson and Daniel H. Haft and Erin K. Hickey and Jeremy D. Peterson and Lowell A. Umayam and Steven R. Gill and Karen E. Nelson and Timothy D. Read and Herv{\'e} Tettelin and Delwood L. Richardson and Maria D. Ermolaeva and Jessica Vamathevan and Steven H. Bass and Haiying Qin and I A Dragoi and Patrick Sellers and Lisa A. McDonald and Teresa R. Utterback and Robert D. Fleishmann and William C. Nierman and Owen White and Steven L. Salzberg and Hamilton O. Smith and Rita R. Colwell and John J. Mekalanos and J. Craig Venter and Claire M. Fraser},
  journal={Nature},
  year={2000},
  volume={406},
  pages={477 - 483}
}
Here we determine the complete genomic sequence of the Gram negative, γ-Proteobacterium Vibrio cholerae El Tor N16961 to be 4,033,460 base pairs (bp). The genome consists of two circular chromosomes of 2,961,146 bp and 1,072,314 bp that together encode 3,885 open reading frames. The vast majority of recognizable genes for essential cell functions (such as DNA replication, transcription, translation and cell-wall biosynthesis) and pathogenicity (for example, toxins, surface antigens and adhesins… Expand
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