DNA sequence insertion and evolutionary variation in gene regulation.

  title={DNA sequence insertion and evolutionary variation in gene regulation.},
  author={Roy John Britten},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 18},
  • Roy John Britten
  • Published 1996 in
    Proceedings of the National Academy of Sciences…
Current evidence on the long-term evolutionary effect of insertion of sequence elements into gene regions is reviewed, restricted to cases where a sequence derived from a past insertion participates in the regulation of expression of a useful gene. Ten such examples in eukaryotes demonstrate that segments of repetitive DNA or mobile elements have been inserted in the past in gene regions, have been preserved, sometimes modified by selection, and now affect control of transcription of the… CONTINUE READING
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The Impact of Short Interspersed Elements (SINEs) on the Host Genome (Landes, Austin, TX)

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