DNA sequence influences hexasome orientation to regulate DNA accessibility

@inproceedings{Brehove2019DNASI,
  title={DNA sequence influences hexasome orientation to regulate DNA accessibility},
  author={Matthew S. Brehove and Elan Shatoff and Benjamin T Donovan and Caroline Jipa and Ralf Bundschuh and Michael G Poirier},
  booktitle={Nucleic acids research},
  year={2019}
}
Nucleosomes, the fundamental organizing units of eukaryotic genomes, contain ∼146 base pairs of DNA wrapped around a histone H3-H4 tetramer and two histone H2A-H2B dimers. Converting nucleosomes into hexasomes by removal of a H2A-H2B dimer is an important regulatory event, but its regulation and functional consequences are not well-understood. To investigate the influence of hexasomes on DNA accessibility, we used the property of the Widom-601 Nucleosome Positioning Sequence (NPS) to form… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 67 REFERENCES

Histone core phosphorylation regulates DNA accessibility.

  • The Journal of biological chemistry
  • 2015
VIEW 4 EXCERPTS

Crystal structure of the nucleosome core particle at 2.8 A resolution

K. Luger, A. W. Mäder, R. K. Richmond, D. F. Sargent, T. J. Richmond
  • Nature
  • 1997
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL