DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene

@article{Nickerson1998DNASD,
  title={DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene},
  author={Deborah A. Nickerson and Scott L. Taylor and Kenneth M. Weiss and Andrew G. Clark and Richard G. Hutchinson and Jari H. Steng{\aa}rd and Veikko V Salomaa and Erkki Vartiainen and Eric Boerwinkle and Charles F. Sing},
  journal={Nature Genetics},
  year={1998},
  volume={19},
  pages={233-240}
}
Lipoprotein lipase plays a central role in lipid metabolism and the gene that encodes this enzyme (LPL) is a candidate susceptibility gene for cardiovascular disease. Here we report the complete sequence of a fraction of the LPL gene for 71 individuals (142 chromosomes) from three populations that may have different histories affecting the organization of the sequence variation. Eighty-eight sites in this 9.7 kb vary among individuals from these three populations. Of these, 79 were single… CONTINUE READING
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