DNA sequence-dependent deformability deduced from protein-DNA crystal complexes.

  title={DNA sequence-dependent deformability deduced from protein-DNA crystal complexes.},
  author={Wilma K. Olson and Andrey A. Gorin and X. J. Lu and Lynette M Hock and Victor B Zhurkin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 19},
The deformability of double helical DNA is critical for its packaging in the cell, recognition by other molecules, and transient opening during biochemically important processes. Here, a complete set of sequence-dependent empirical energy functions suitable for describing such behavior is extracted from the fluctuations and correlations of structural parameters in DNA-protein crystal complexes. These elastic functions provide useful stereochemical measures of the local base step movements… CONTINUE READING
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