DNA replication origins in the Schizosaccharomyces pombe genome.

  title={DNA replication origins in the Schizosaccharomyces pombe genome.},
  author={Jianli Dai and R Y Chuang and Thomas B Kelly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 2},
Origins of DNA replication in Schizosaccharomyces pombe lack a specific consensus sequence analogous to the Saccharomyces cerevisiae autonomously replicating sequence (ARS) consensus, raising the question of how they are recognized by the replication machinery. Because all well characterized S. pombe origins are located in intergenic regions, we analyzed the sequence properties and biological activity of such regions. The AT content of intergenes is very high ( approximately 70%), and runs of A… CONTINUE READING


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