DNA replication origins: from sequence specificity to epigenetics.

@article{Mchali2001DNARO,
  title={DNA replication origins: from sequence specificity to epigenetics.},
  author={Marcel M{\'e}chali},
  journal={Nature reviews. Genetics},
  year={2001},
  volume={2 8},
  pages={640-5}
}
Site-specific initiation of DNA replication is a conserved function in all organisms. In Escherichia coli and Saccharomyces cerevisiae, DNA replication origins are sequence specific, but in multicellular organisms, origins are not so clearly defined. In this article, I present a model of origin specification by epigenetic mechanisms that allows the establishment of stable chromatin domains, which are characterized by autonomous replication. According to this model, origins of DNA replication… CONTINUE READING
45 Citations
80 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 80 references

ADAPTIVE MUTATION Susan M

  • L. Lu, Tower, J. A transcriptional insulator element, the NATURE REVIEWS GENETICS VOLUME 2 AUGUST 2001 645 C RESPONSIVELY
  • Rosenberg Nature Reviews Genetics 2, 504–515
  • 2001

Similar Papers

Loading similar papers…