DNA replication licensing.

  title={DNA replication licensing.},
  author={Hideo Nishitani and Zoi Lygerou},
  journal={Frontiers in bioscience : a journal and virtual library},
The DNA replication licensing system ensures that chromosomal DNA is replicated precisely once before cell division occurs. A DNA helicase must be loaded on origin DNA for replication to initiate. Considerable evidence suggests that the MCM complex acts as a replicative helicase in eukaryotes. When the MCM complex is loaded on the chromatin, the replication origin is formally defined as being licensed for replication. Licensing takes place several hours before origins are activated to undergo… CONTINUE READING
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