DNA replication licensing in peripheral B-cell lymphoma.

  title={DNA replication licensing in peripheral B-cell lymphoma.},
  author={Ellen Christina Obermann and Kathryn Leigh Eward and A. Latif Dogan and Elizabeth A. Paul and Marco Loddo and Philippa Munson and Gareth Haydn Williams and Kai Stoeber},
  journal={The Journal of pathology},
  volume={205 3},
Peripheral B-cell lymphomas representing 90% of lymphoid neoplasms are divided into low- and high-growth fraction lymphomas. Here we investigate regulation of DNA replication licensing during B-cell lymphomagenesis. Combined analysis of origin licensing factors Mcm2 and geminin with the proliferation marker Ki67 in SLL/CLL, MCL, DLBCL and Burkitt lymphoma reveals for the first time the precise cell cycle state of these entities. Given that tight Mcm2 downregulation defines the quiescent state… CONTINUE READING


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