DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts

@article{Stokes2002DNARI,
  title={DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts},
  author={Matthew P. Stokes and Ruth A. Van Hatten and Howard D Lindsay and W Matthew Michael},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={158},
  pages={863 - 872}
}
Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the damage and activates the checkpoint is not yet understood. To address this issue for alkylation damage, we have reconstituted the checkpoint response to MMS in Xenopus egg extracts. Using four different indicators for checkpoint activation (delay on… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Phos - phorylation of serines 635 and 645 of human Rad 17 is cell cycle regulated and is required for G ( 1 ) / S checkpoint activation in response to DNA dam

  • E. C. Busby, R. S. Tibbetts, P. Roos, Y. Taya, L. M. Karnitz, R. T. Abraham
  • Proc . Natl . Acad . Sci . USA .
  • 2001

Similar Papers

Loading similar papers…