DNA replication initiation: mechanisms and regulation in bacteria

  title={DNA replication initiation: mechanisms and regulation in bacteria},
  author={Melissa L. Mott and James M Berger},
  journal={Nature Reviews Microbiology},
In all organisms, multi-subunit replicases are responsible for the accurate duplication of genetic material during cellular division. Initiator proteins control the onset of DNA replication and direct the assembly of replisomal components through a series of precisely timed protein–DNA and protein–protein interactions. Recent structural studies of the bacterial protein DnaA have helped to clarify the molecular mechanisms underlying initiator function, and suggest that key structural features of… CONTINUE READING
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Functional dissection of YabA, a negative regulator of DNA replication initiation in Bacillus subtilis

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