DNA replication in the face of (In)surmountable odds.

  title={DNA replication in the face of (In)surmountable odds.},
  author={J. E. Cleaver and Rebecca R. Laposa and Charles L. Limoli},
  journal={Cell cycle},
  volume={2 4},
We describe here a model for sequential recruitment of various enzymatic systems that maintain DNA replication fidelity in cells with damaged bases, especially those formed by ultraviolet (UV) irradiation. Systems of increasing complexity but decreasing fidelity are recruited to restore replication of damaged DNA. The first and most accurate response is nucleotide excision repair (NER) that is cell cycle-independent; next come various delaying cell cycle checkpoints that provide an extended… CONTINUE READING