DNA replication-dependent intranuclear relocation of double minute chromatin.

  title={DNA replication-dependent intranuclear relocation of double minute chromatin.},
  author={Naoki Itoh and Noriaki Shimizu},
  journal={Journal of cell science},
  volume={111 ( Pt 22)},
Double minutes (DMs) seen in a substantial fraction of human tumors are the cytogenetic manifestation of gene amplification which renders the tumor cells advantageous for growth and survival. DMs are acentric and atelomeric chromatin composed of circular DNA. In this study, we found they showed a remarkable relocation inside the nucleus which was spatially and temporally coupled to DNA replication. Using the human COLO 320DM tumor line, we detected DMs by fluorescence in situ hybridization… CONTINUE READING


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