DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1.

@article{Bruin2008DNARC,
  title={DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1.},
  author={Robertus Antonius Maria de Bruin and Tatyana I Kalashnikova and Aaron Aslanian and James A Wohlschlegel and Charly Chahwan and John R. Yates and Paul Russell and Curt Wittenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 32},
  pages={11230-5}
}
The cell cycle transcriptional program imposes order on events of the cell-cycle and is a target for signals that regulate cell-cycle progression, including checkpoints required to maintain genome integrity. Neither the mechanism nor functional significance of checkpoint regulation of the cell-cycle transcription program are established. We show that Nrm1, an MBF-specific transcriptional repressor acting at the transition from G(1) to S phase of the cell cycle, is at the nexus between the cell… CONTINUE READING

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