DNA replication at the single-molecule level.

  title={DNA replication at the single-molecule level.},
  author={S. Stratmann and A. V. van Oijen},
  journal={Chemical Society reviews},
  volume={43 4},
  • S. Stratmann, A. V. van Oijen
  • Published 2014
  • Computer Science, Medicine
  • Chemical Society reviews
  • A cell can be thought of as a highly sophisticated micro factory: in a pool of billions of molecules - metabolites, structural proteins, enzymes, oligonucleotides - multi-subunit complexes assemble to perform a large number of basic cellular tasks, such as DNA replication, RNA/protein synthesis or intracellular transport. By purifying single components and using them to reconstitute molecular processes in a test tube, researchers have gathered crucial knowledge about mechanistic, dynamic and… CONTINUE READING
    23 Citations

    Figures and Topics from this paper

    High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.
    • 40
    • PDF


    Single-molecule studies of complex systems
    • 12
    • PDF
    Replisome-mediated DNA replication.
    • 289
    • PDF
    Prokaryotic DNA replication mechanisms.
    • B. M. Alberts
    • Biology, Medicine
    • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    • 1987
    • 70
    Motors, switches, and contacts in the replisome.
    • 153
    • PDF