DNA replication and inactivation patterns in structural abnormality of sex chromosomes

@article{Camargo2004DNARA,
  title={DNA replication and inactivation patterns in structural abnormality of sex chromosomes},
  author={Mauricio Camargo and Jaroslav Cervenka},
  journal={Human Genetics},
  year={2004},
  volume={67},
  pages={37-47}
}
High resolution chromosome analysis and bromodeoxyuridine (BrdUrd) incorporation have been applied to study patterns of chromosomal replication (inactivation) in two cases of unbalanced X-autosome translocations, seven cases of X and Y chromosome rings or fragments, and five cases of dicentric isochromosomes (Xq). Our results indicate the following: (1) In (X-A) translocations, detailed replicational analysis of the translocated autosomal segment is informative. Absence of “spreading effect… CONTINUE READING
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