DNA replication: Controlling initiation during the cell cycle

  title={DNA replication: Controlling initiation during the cell cycle},
  author={Marco Muzi-Falconi and Grant W Brown and Thomas B Kelly},
  journal={Current Biology},
The replication of the genome of a eukaryotic cell is a tightly regulated process. Firstly, replication is coordinated with general macromolecular synthesis, so that the DNA-to-protein ratio is maintained within a relatively narrow range. This involves a mechanism that couples the initiation of DNA replication to the achievement of a critical cell size. Secondly, replication generates exactly two copies of each DNA segment. This is accomplished by a molecular switch that restricts the… CONTINUE READING
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