DNA repair proteins and telomerase reverse transcriptase in the cochlear lateral wall of cisplatin-treated rats.

@article{Guthrie2009DNARP,
  title={DNA repair proteins and telomerase reverse transcriptase in the cochlear lateral wall of cisplatin-treated rats.},
  author={O'neil W. Guthrie},
  journal={Journal of chemotherapy},
  year={2009},
  volume={21 1},
  pages={74-9}
}
Cochlear lateral wall damage is a side effect of cisplatin chemotherapy. Recent studies have shown that cisplatin treatment precipitates platinated DNA adducts in the cochlear lateral wall which suggest that DNA damage may contribute to ototoxicity. Platinated adducts are high-affinity substrates for the global genomic nucleotide excision repair (GG-NeR) pathway which is facilitated by xeroderma pigmentosum (Xp) complementing proteins, such as XpC, XpD and XpA. tumor biology has shown that in… CONTINUE READING