DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes.

@article{Kennedy2006DNARP,
  title={DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes.},
  author={Richard D. Kennedy and Alan D' Andrea},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 23},
  pages={3799-808}
}
Human cancers exhibit genomic instability and an increased mutation rate due to underlying defects in DNA repair. Cancer cells are often defective in one of six major DNA repair pathways, namely: mismatch repair, base excision repair, nucleotide excision repair, homologous recombination, nonhomologous endjoining and translesion synthesis. The specific DNA repair pathway affected is predictive of the kinds of mutations, the tumor drug sensitivity, and the treatment outcome. The study of rare… CONTINUE READING
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