DNA repair in premature aging disorders and neurodegeneration.

  title={DNA repair in premature aging disorders and neurodegeneration.},
  author={Fabio Copped{\`e} and Lucia Migliore},
  journal={Current aging science},
  volume={3 1},
The accumulation of DNA damage has been widely implicated in premature aging and neurodegeneration. Progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect of the aging process. Moreover, most of the major neurodegenerative diseases are characterized by the accumulation of neuronal DNA damage, suggesting that impaired DNA repair mechanisms might be relevant to both premature aging and neurodegeneration… CONTINUE READING
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