DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging.

@article{Boesch2011DNARI,
  title={DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging.},
  author={Pierre Boesch and Fr{\'e}d{\'e}rique Weber-Lotfi and Noha E Ibrahim and Vladislav I Tarasenko and Anne Cosset and François Paulus and Robert N Lightowlers and Andre Dietrich},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1813 1},
  pages={186-200}
}
Both endogenous processes and exogenous physical and chemical sources generate deoxyribonucleic acid (DNA) damage in the nucleus and organelles of living cells. To prevent deleterious effects, damage is balanced by repair pathways. DNA repair was first documented for the nuclear compartment but evidence was subsequently extended to the organelles. Mitochondria and chloroplasts possess their own repair processes. These share a number of factors with the nucleus but also rely on original… CONTINUE READING