DNA repair in cancer: emerging targets for personalized therapy

@inproceedings{Abbotts2014DNARI,
  title={DNA repair in cancer: emerging targets for personalized therapy},
  author={Rachel Abbotts and Nicola Thompson and Srinivasan Madhusudan},
  booktitle={Cancer management and research},
  year={2014}
}
Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity. Impaired DNA repair is a major driver for carcinogenesis and could promote aggressive cancer biology. Interestingly, in established tumors, DNA repair activity is required to counteract oxidative DNA damage that is prevalent in the tumor microenvironment. Emerging… CONTINUE READING
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