DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk.

@article{Andrew2009DNARG,
  title={DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk.},
  author={Angeline S. Andrew and Rebecca A. Mason and Karl T. Kelsey and Alan R. Schned and Carmen J. Marsit and Heather H. Nelson and Margaret R. Karagas},
  journal={Toxicology letters},
  year={2009},
  volume={187 1},
  pages={10-4}
}
Drinking water arsenic exposure has been associated with increased bladder cancer susceptibility. Epidemiologic and experimental data suggest a co-carcinogenic effect of arsenic with exposure to DNA damaging agents, such as cigarette smoke. Recent evidence further supports the hypothesis that genetic variation in DNA repair genes can modify the arsenic-cancer relationship, possibly because arsenic impairs DNA repair capacity. We tested this hypothesis in a population-based study of bladder… CONTINUE READING
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