DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial.

@article{Doherty2013DNARG,
  title={DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial.},
  author={Jennifer A Doherty and Lori C. Sakoda and Melissa M. Loomis and Matt J. Barnett and Liberto Julianto and Mark Thornquist and Marian L Neuhouser and Noel S Weiss and Gary E. Goodman and Chu Chen},
  journal={International journal of molecular epidemiology and genetics},
  year={2013},
  volume={4 1},
  pages={11-34}
}
Many carcinogens in tobacco smoke cause DNA damage, and some of that damage can be mitigated by the actions of DNA repair enzymes. In a case-control study nested within the Beta-Carotene and Retinol Efficacy Trial, a randomized chemoprevention trial in current and former heavy smokers, we examined whether lung cancer risk was associated with variation in 26 base excision repair, mismatch repair, and homologous recombination repair genes. Analyses were limited to Caucasians (744 cases, 1477… CONTINUE READING