DNA repair dysfunction in gastrointestinal tract cancers.

  title={DNA repair dysfunction in gastrointestinal tract cancers.},
  author={Yoshihiko Maehara and Akinori Egashira and Eiji Oki and Yoshihiro Kakeji and Teruhisa Tsuzuki},
  journal={Cancer science},
  volume={99 3},
The DNA repair system surveys the genome, which is always suffering from exposure to both exogenous as well as endogenous mutagens, to maintain the genetic information. The fact that the basis of this DNA repair system is highly conserved, from prokaryote to mammalian cells, suggests the importance of precise genome maintenance mechanisms for organisms. In the past 15 years, considerable progress has been made in understanding how repair processes interact and how disruptions of these… CONTINUE READING


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