DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells.

@article{Shivji1994DNARD,
  title={DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells.},
  author={Mahmud K.K Shivji and Andr{\'e} Eker and Richard D Wood},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 36},
  pages={22749-57}
}
A predominant form of the inherited syndrome xeroderma pigmentosum is genetic complementation group C (XP-C). XP-C cells are defective in DNA nucleotide excision repair in the bulk of the genome but can repair transcribed strands of active genes. An activity that can complement the repair deficiency of extracts from XP-C cells has been purified approximately 2,000-fold from HeLa cells. The factor also increases the unscheduled DNA synthesis of XP-C fibroblasts in vivo after microinjection… CONTINUE READING

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