DNA regions bound at low occupancy by transcription factors do not drive patterned reporter gene expression in Drosophila.

@article{Fisher2012DNARB,
  title={DNA regions bound at low occupancy by transcription factors do not drive patterned reporter gene expression in Drosophila.},
  author={William W. Fisher and Jingyi Jessica Li and Ann Hammonds and J. Ben Brown and Barret D. Pfeiffer and Richard Weiszmann and Stewart MacArthur and Sean Thomas and John A. Stamatoyannopoulos and Michael B. Eisen and Peter J. Bickel and Mark D. Biggin and Susan E. Celniker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 52},
  pages={21330-5}
}
In animals, each sequence-specific transcription factor typically binds to thousands of genomic regions in vivo. Our previous studies of 20 transcription factors show that most genomic regions bound at high levels in Drosophila blastoderm embryos are known or probable functional targets, but genomic regions occupied only at low levels have characteristics suggesting that most are not involved in the cis-regulation of transcription. Here we use transgenic reporter gene assays to directly test… CONTINUE READING
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Global analysis of patterns of gene expression during Drosophila embryogenesis

P Tomancak
Genome Biol • 2007

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