DNA recognition by beta-sheets in the Arc repressor-operator crystal structure.

@article{Raumann1994DNARB,
  title={DNA recognition by beta-sheets in the Arc repressor-operator crystal structure.},
  author={Brigitte Elke Raumann and Mark A. Rould and Carl O. Pabo and Robert T. Sauer},
  journal={Nature},
  year={1994},
  volume={367 6465},
  pages={754-7}
}
Transcription of the ant gene during lytic growth of bacteriophage P22 (ref. 1) is regulated by the cooperative binding of two Arc repressor dimers to a 21-base-pair operator site. Here we report the co-crystal structure of this Arc tetramer-operator complex at 2.6 A resolution. As expected from genetic and structural studies and from the co-crystal structure of the homologous Escherichia coli MetJ repressor, each Arc dimer uses an antiparallel beta-sheet to recognize bases in the major groove… CONTINUE READING