DNA recognition by DNase I.

  title={DNA recognition by DNase I.},
  author={Dietrich Suck},
  journal={Journal of molecular recognition : JMR},
  volume={7 2},
  • Dietrich Suck
  • Published 1994 in Journal of molecular recognition : JMR
Bovine pancreatic DNase I shows a strong preference for double-stranded substrates and cleaves DNA with strongly varying cutting rates suggesting that the enzyme recognises sequence-dependent structural variations of the DNA double helix. The complicated cleavage pattern indicates that several local as well as global helix parameters influence the cutting frequency of DNase I at a given bond. The high resolution crystal structures of two DNase I-DNA complexes showed that the enzyme binds… CONTINUE READING

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