DNA rearrangements linked to expression of a predominant surface antigen gene of trypanosomes

@article{Laurent1983DNARL,
  title={DNA rearrangements linked to expression of a predominant surface antigen gene of trypanosomes},
  author={M. Laurent and E. Pays and Eddy Magnus and Nestor Van Meirvenne and Gaston E. Matthyssens and Richard O. Williams and M. Steinert},
  journal={Nature},
  year={1983},
  volume={302},
  pages={263-266}
}
African trypanosomes show an extensive capacity for antigenic variation1–6. The serotype of each antigenic variant is determined by a variant-specific surface antigen (VSA) which forms a continuous coat over the entire surface of the parasite7. All known VSAs are glycoproteins whose antigenic specificity is associated with the protein moiety8,9. The expression of some of the VSA genes is linked to the duplication of a ‘basic’ copy (BC) of the gene and to the transposition of the additional or… CONTINUE READING