DNA rearrangement mediated by inverted repeats.

@article{Bi1996DNARM,
  title={DNA rearrangement mediated by inverted repeats.},
  author={X Bi and L. F. Liu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 2},
  pages={
          819-23
        }
}
  • X. Bi, L. Liu
  • Published 1996
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Inverted repeats of DNA are widespread in the genomes of eukaryotes and prokaryotes and can mediate genome rearrangement. We studied rearrangement mediated by plasmid-borne inverted repeats in Escherichia coli. We show that inverted repeats can mediate an efficient and recA-independent recombination event. Surprisingly, the product of this recombination is not that of simple inversion between the inverted repeats, but almost exclusively an unusual head-to-head dimer with complex DNA… Expand
Inverted repeats as genetic elements for promoting DNA inverted duplication: implications in gene amplification.
TLDR
The results suggest a model in which inverted repeats near the ends of a double-strand break can be processed by a helicase/exonuclease to form hairpin caps, suggesting conservation of this type of genome instability from bacteria to mammalian cells. Expand
Inversion/dimerization of plasmids mediated by inverted repeats.
In contrast with earlier studies on the lambda and Escherichia coli genomes, recombination between inverted repeats on plasmids is highly efficient and shown to be recA-independent. In addition, theExpand
Factors affecting inverted repeat stimulation of recombination and deletion in Saccharomyces cerevisiae.
TLDR
The results support a model in which the stimulation of deletion and recombination by inverted repeats is initiated by a secondary structure formed between single-stranded DNA of inverted repeats during replication, and the presence of a strong origin of replication in the spacer reduced both rates of deletion. Expand
Misalignment-Mediated Mutations and Genetic Rearrangements at Repetitive DNA Sequences
TLDR
This chapter catalogs several types of misalignment-mediated genetic changes in bacteria, with an emphasis on the mechanisms by which they occur. Expand
recA-independent DNA recombination between repetitive sequences: mechanisms and implications.
  • X. Bi, L. Liu
  • Biology, Medicine
  • Progress in nucleic acid research and molecular biology
  • 1996
Publisher Summary This chapter discusses the distinct features of recA -independent recombination among repetitive sequences in bacteria, with special emphasis on replicational models and theirExpand
Formation of large palindromic DNA by homologous recombination of short inverted repeat sequences in Saccharomyces cerevisiae.
TLDR
The evidence supports a model in which palindromes are primarily formed by an intermolecular reaction involving homologous recombination of short inverted repeat sequences, and the requirement for DNA double-strand break repair genes in palindrome formation is extended. Expand
Observations on template switching during DNA replication through long inverted repeats.
TLDR
Analysis of DNA replication through Tn5 by two-dimensional gel electrophoresis implies that the inviability of palindromic DNA, which has been attributed to the slowing down of replication, may actually be caused by frequent template switching. Expand
Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast.
TLDR
It is proposed that fusion of nearby inverted repeats to form dicentrics may be a major cause of instability in yeast and in other organisms by a DSB-independent, DNA replication-based mechanism (which the authors term "faulty template switching"). Expand
Altered replication and inverted repeats induce mismatch repair-independent recombination between highly diverged DNAs in yeast
TLDR
It is proposed that the dramatic increase in recombination results from enhancement of the effects of altered replication by the LIR, leading to recombinationally active initiating structures, which predict replication-related, MMR-independent genome changes. Expand
Leaping forks at inverted repeats.
TLDR
It is demonstrated that nearby inverted repeats in budding and fission yeasts recombine spontaneously and frequently to form dicentric and acentric chromosomes. Expand
...
1
2
3
4
5
...