DNA rearrangement affecting expression of the BK virus transforming gene.


BK virus mutant pm-522, forming small turbid plaques on human cells, can transform rat or hamster cells much more efficiently than the wild-type BK virus (wt-501) does. We compared the nucleotide sequence of wt-501 HindIII C segment with that of pm-522 HindIII-C, which contains the mutation responsible for the altered plaque type and transforming capacity… (More)


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